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Project S01: Central recruitment, imaging and biobanking

Project S01 will be responsible for the recruitment and support the basic characterization of the central cohort of 1050 subjects for projects A01-A04. S01 will coordinate the acquisition and quality assurance of a basic neurocognitive and neuroimaging battery (anatomical MRI, resting state MRI, fMRI during inhibitory control), and the biobanking of blood, as well as genome-wide genetic and epigenetic analyses. S01 will provide 15 subprojects of the CRC/TRR 265 with pre-processed psychometric-, MRI- and genetic data to be included in the outcome variable analyses.

Principal Investigators:
Prof. Dr. Bernd Lenz, Zentralinstitut für Seelische Gesundheit Mannheim
Ph.D. Michael Marxen, Technische Universität Dresden
Prof. Dr. Marcella Rietschel, Zentralinstitut für Seelische Gesundheit Mannheim
Prof. Dr. Dr. Henrik Walter, Charité – Universitätsmedizin Berlin

Project members:
Dr. Patrick Bach, Zentralinstitut für Seelische Gesundheit Mannheim
Pascale Fischbach, Technische Universität Dresden
Dr. Johannes Petzold, Technische Universität Dresden
Pablo Reinhardt, Charité - Universitätsmedizin Berlin
Friederike Wedemeyer, Charité - Universitätsmedizin Berlin
Julia Wenzel, Charité - Universitätsmedizin Berlin
PD Dr. Stephanie Witt, Zentralinstitut für Seelische Gesundheit Mannheim

Project S02: Mobile infrastructure for daily life research

We will develop and implement a mobile research infrastructure combining longitudinal assessments (A01) with two high-intensity measurement bursts (A04). MovisensXS will be used as a platform to assess e-diary items and track smartphone usage. Connected additional devices will capture physical activity and heart rate variability. All data will be sent via encrypted transmission to a secured server ensuring compliance with GDPR. Real-time analyses on all acquired data will allocate information on compliance and probability of phase changes. We will provide hard- and software interfaces to enable integration of apps (A02) and sensors (A03), as well as extensive training, ongoing support and troubleshooting.

Principal Investigators:
Prof. Dr. Ulrich Ebner-Priemer, Karlsruhe Institute of Technology
Prof. Dr. Andreas Meyer-Lindenberg, Zentralinstitut für Seelische Gesundheit Mannheim
Prof. Dr. Jan Stallkamp, Fraunhofer Institute for Manufacturing Engineering and Automation, Mannheim

Project INF: Information infrastructure

Research data management is a prerequisite of reproducibility of research and FAIR data. This CRC/TRR will gather a wide variety of different datasets in humans and animals, in different labs and sites. The recruitment and assessment of large participant samples needs to be managed as well as quality control of the data. For collaborative work, a Virtual Research Environment (VRE) will be set up to collect, manage, describe, analyze, archive and share the data between the researchers, as well as with the scientific community (Open Data). Based on existing methods and tools (e.g. from CRC 940 and CRC/TRR 205), we will develop the system to specifically meet the needs of CRC/TRR 265 in close cooperation with the researchers.

Principal Investigators:
Prof. Dr. Wolfgang E. Nagel, Technische Universität Dresden
Prof. Dr. Michael Smolka, Technische Universität Dresden

Project members:
Alvaro Aguilera, Technische Universität Dresden
Christian Löschen, Technische Universität Dresden
Dr. Ralph Müller-Pfefferkorn, Technische Universität Dresden
Jens Strehle, Technische Universität Dresden
Dr. Gesine Wieder, Technische Universität Dresden

Project Z: Central tasks of the collaborative research center

The central administration will provide the necessary infrastructure and service support for all projects of the CRC/TRR 265 and will deal with all administrative tasks. Moreover, it will pursue an ambitious program, both in terms of encouraging interaction between the CRC/TRR 265 project groups, and in terms of interaction with the wider scientific community and the general public. Apart from the day-to-day business of administrating the CRC, the following measures are planned: a) extensive measures to communicate CRC/TRR 265 research to the public, particularly stakeholder groups of patients and their relatives; b) a well-developed scientific interaction program that places young researchers in focus and provides both a summer school and an international conference; c) a strong commitment to equal opportunity measures.

Principal Investigator:
Prof. Dr. Dr. Andreas Heinz, Charité – Universitätsmedizin Berlin

Project members:
Dr. Shuyan Liu, Charité - Universitätsmedizin Berlin
Dr. Lydia Romund, Charité - Universitätsmedizin Berlin