Collaborative Research Centre TRR 265: Losing and Regaining Control over Drug Intake 

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Collaborative Research Center TRR 265: Losing and regaining control over drug intake

The major risk factor for global death and disability is alcohol and tobacco use. While insight into individual factors promoting the initiation and maintenance of substance use is increasing, a profound lack of knowledge remains as regards modulating factors and mechanisms involved in losing and regaining control over drug intake. Improving treatment of substance use disorders (SUDs) a better understanding of these factors and mechanisms will be crucial to improve treatment of substance use disorders.

The goal of our research consortium is to identify the trajectories of losing and regaining control over drug consumption, to study underlying neurobiological and learning mechanisms, and to provide mechanism-based therapies. These goals will be achieved by (i) using innovative mobile Health (m-Health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modifying factors (e.g. age, gender, physical activity, cognitive functions) on alcohol and tobacco consumption patterns in real life conditions and in animal models of addiction, (ii) by the identification and computational modelling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual and compulsive aspects of drug consumption in corresponding human studies and animal experiments (tandem projects), and (iii) by subsequently developing interventions that specifically target the underlying mechanisms for regaining control over drug intake.

The trans-regional collaboration project will be funded with 12 million Euro for four years by the Germany Research Foundation (DFG).

Steering committee

Spokesperson of the CRC

Prof. Dr. med. Dr. phil. Andreas Heinz

Spokesperson TRR 265, Director of the Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin

CCM: Campus Charité Mitte

Deputy Spokespersons

Prof. Dr. med. Dr. phil. Heike Tost

Deputy Spokesperson TRR 265 (Coordination of Ecological Momentary assessment), Dipl.-Psych., Physician, Head of the Research Group Systems Neuroscience Psychiatry (SNiP), ZI Mannheim

Prof. Dr. med. Falk Kiefer

Deputy Spokesperson TRR 265 (Local Spokesperson Mannheim and Clinical assessment), medical director Department of Addictive Behaviour & Addiction, ZI Mannheim

Prof. Dr. med. Michael Smolka

Deputy Spokesperson TRR 265 (Local Spokesperson Dresden and Computational Modelling), Head of the Section of Systems Neuroscience, TU Dresden

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